Ortho Pthalaldehyde Advantage Over other Disinfectants
ortho-phthalaldehyde (OPA) has been accepted as a better, safer alternative to glutaraldehyde in most healthcare facilities. Cleared by the US FDA as a high-level disinfectant and emerged as a suitable replacement of glutaraldehyde for the disinfection of endoscopes. OPA has excellent microbicidal activity and superior mycobactericidal activity compared to glutaraldehyde, and has potent bactericidal and sporicidal activity. OPA has many advantages over glutaraldehyde, such as improved stability at varying pH ranges, lower inhalation exposure risk and a wider range of material compatibility. It requires no activation, is not a known irritant to the eyes and nasal passages and does not require exposure monitoring.
Orthopthalaldehyde over glutaraldehyde resistant Micro Bacterium
OPA has shown superior mycobactericidal activity (5-log10 reduction in 5 minutes) compared to glutaraldehyde. The mean time required to effect a 6-log10 reduction for M. Bovis using 0.21% OPA was 6 minutes, compared to 32 minutes using 1.5% glutaraldehyde. Ortho-phthalaldehyde (0.55%) is a very good alternative to the widely used Glutaraldehyde (2%) for high-level disinfection